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Sunday, April 19, 2020 | History

2 edition of High-dose Platinol (cisplatin for infection) in hypertonic saline found in the catalog.

High-dose Platinol (cisplatin for infection) in hypertonic saline

Robert F. Ozols

High-dose Platinol (cisplatin for infection) in hypertonic saline

  • 27 Want to read
  • 7 Currently reading

Published by Bristol-Myers Oncology Division in Syracuse, N.Y .
Written in English

    Subjects:
  • Testis -- Cancer -- Chemotherapy -- Evaluation.,
  • Ovaries -- Cancer -- Chemotherapy -- Evaluation.,
  • Cisplatin -- Testing.,
  • Cisplating -- Dosage forms -- Testing.,
  • Hypertonic solutions -- Therapeutic use -- Testing.

  • Edition Notes

    Bibliography: p. 20-21.

    StatementRobert F. Ozols.
    Classifications
    LC ClassificationsRC280.T4 O98 1985
    The Physical Object
    Pagination24 p. :
    Number of Pages24
    ID Numbers
    Open LibraryOL2313664M
    LC Control Number86193601

    References. 1) Gisselbrecht C, Glass B, Mounier N, et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol. ; 2) Kewalramani T, Zelenetz AD, Nimer SD, et al. Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma.


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High-dose Platinol (cisplatin for infection) in hypertonic saline by Robert F. Ozols Download PDF EPUB FB2

The benefit of adding concomitant high-dose cisplatin to adjuvant radiotherapy (RT) for resected head and neck squamous cell carcinoma (HNSCC) was established in two large seminal trials, EORTC and RTOG In these studies, cisplatin was administered at a dose of mg/m 2 on days 1, 22, and 43 during radiation.

Subsequent large robust trials in the postoperative setting Author: Alesha A. Thai, Danny Rischin. numbness or tingling in fingers or toes. trouble in walking. Agitation or confusion. change in ability to see colors (especially blue or yellow) sores in mouth and on lips.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Also, your. Clinical trials are research studies that involve people. The clinical trials on this list are studying Cisplatin. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out.

Clinical trials. Cisplatin, a platinum-based chemotherapy drug, is commonly used for the treatment of many cancers, including bladder, ovarian, and testicular cancers. But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant permanent hearing loss, a condition.

Doxorubicin side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face/ 25 mg/week, high-dose regimens, or dose adjustments of less than 5 mg incre-ments.

Subcut:Otrexup is a single-dose auto-injector. Injectonce weeklyinabdomen or upper thigh. Avoid areas where skin is tender, bruised, red, scaly, hard, or has onisclearandyellow;donotinjectsolutionsthatare File Size: KB. Cisplatin (Platinol, Platinol-AQ) usually given intravenously (IV) decrease in blood cell counts: used for cancers of the bladder, ovary, and testicles ; allergic reaction, including a rash and/or labored breathing (rare) nausea and vomiting that usually occurs for 24 hours or longer: ringing in ears and hearing loss.

Doctors have used chemotherapy (chemo) to treat cancer since the s. The advantage to these drugs is they kill cancer cells throughout your body. One downside is the side effects they can cause. The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled study.

Hematol Oncol. Mar;30(1) View abstract. Navigating Care is a full community of cancer survivors, caregivers, professionals and friends & family who support one another, share their experiences, discuss.

drugs: chemotherapy drugs and other pharmaceuticals Many different types of drugs are used during treatment for childhood cancers: chemotherapy drugs, antibiotics, anti-emetics, and others.

The coverage on this ACCO-developed web page is intended to provide basic information about each drug and what it is intended to treat, as well as to give.

Low doses of chemotherapy drugs such as cisplatin (Platinol®) are used during this treatment to sensitize the cancer cells to radiation therapy. Internal radiation is then given using high-dose brachytherapy, in which high doses of radioactive material are applied through a specialized applicator directly to the tumor.

Studies have shown that. Among adults who received high-dose methotrexate (median dose of mg/m2, range of mg/m2), coadministration of PPIs such as omeprazole, lansoprazole, or rabeprazole was identified as a risk factor for delayed methotrexate elimination with an OR of (95% confidence interval ).

I completed my 18 weeks of Taxol/Carbo treatment 5 weeks ago today. I did very well on the chemo with relatively few side effects apart from weight gain (arghhhh) and hair loss. Anyway about weeks after completing the treatment i started to get aching muscles and painful joints especially knees and fingers.

Drug Interactions in Cancer Patients Requiring Concomitant Chemotherapy and Analgesics As more cancer drugs are prescribed in outpatient settings, there is a greater need to ensure that patients are monitored for potential adverse events related to their dual chemotherapy and analgesic regimens.

Study Shows Benefits of Adding High-Dose Calcitriol to Chemotherapy for Advanced Prostate Cancer: Presented at ASCO - Calcitriol May Safely Double Effectiveness of Taxotere Treatment.

ORLANDO, FL — — The addition of high-dose calcitriol to weekly treatment with the chemotherapy agent docetaxel (Taxotere®) appears to improve the therapeutic response in men with. Yes, some conventional chemotherapy drugs used to treat cancer can increase your risk of heart problems.

Heart problems can also happen with newer targeted therapy drugs and with radiation therapy. Examples of heart-related problems that can happen with cancer treatments include: Whether you're at risk for heart problems during and after cancer.

Patients’ Guide to Cervical Cancer. Jones & Bartlett Publishers, - Cervix uteri - pages. 0 Reviews. Preview this book.

the same high-dose therapy at disease progression. All sites of bony disease were irradiated after high-dose therapy (in patients randomized to the immediate high-dose arm) or at randomization to observation. Of the 85 patients enrolled, 69 were randomized 35 to immediate high-dose therapy and 34 to by: 7.

When the book was published, they were waiting on the new drugs, taxol and Platinol, to see how the survival rates would increase if they would. Reflection I can imagine how women with ovarian cancer feel when they find out that its been developing for a long time yet.

Stage IV breast cancer was traditionally been considered an incurable cancer. In the mid to late ’s the average patient with stage IV breast cancer treated with low-dose chemotherapy survived months before their cancer relapsed and less than 5% of patients could expect to survive 5 years without their cancer recurring.

Introduction. Breast cancer is the second leading cause of deaths in women after lung cancer and it is the most common cancer among women worldwide (23% of all new cancer cases)-negative breast cancer (TNBC) refers to the breast cancer phenotype where the estrogen and progesterone receptor are negative, as assessed by immunohistochemistry (IHC) and there is a Cited by: A patient who is receiving high-dose chemotherapy with methotrexate is also receiving leucovorin.

The purpose of the leucovorin is to: A. produce an additive effect with the methotrexate by increasing its potency against the cancer cells. reduce the incidence of cardiomyopathy caused by the methotrexate.

Mar 6, - Explore lin's board "kaplan qbank pharmacology" on Pinterest. See more ideas about Pharmacology, Content media and Medical mnemonics pins. US-based MDs, DOs, NPs and PAs in full-time patient practice can register for free on is to be used only as a reference aid.

It is not intended to be a substitute for the exercise of professional judgment. You should confirm the information on the site through independent sources and seek other professional guidance in.

This chapter will be most useful after having a basic understanding of the material in Chapter 60 General Principles of Cancer Chemotherapy and Chapter 61 Cytotoxic Agents in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition. In addition to the material presented here, Chapters 60 and 61 of the 12th Edition contain.

Cyclophosphamide does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions. Use aseptic technique. For Direct Intravenous Injection.

Reconstitute Cyclophosphamide with % Sodium Chloride Injection, USP only, using the volumes listed. Chemotherapy is usually given in an outpatient setting, such as a hospital, clinic, or doctor's office. Patients receiving chemotherapy will be watched for reactions during treatments. Since each chemotherapy treatment session may last for a while, patients are encouraged to take along something that is comforting, such as music to listen to.

Cancer pharmacology offers an integrated body of practical knowledge that is valuable for the full range of activities related to cancer therapeutics, from everyday clinical treatment decisions, to assisting clinical trial design in drug development, to discovery and evaluation.

Start studying Chemotherapy, Radiation- Lewis 9th edition (med surg). Learn vocabulary, terms, and more with flashcards, games, and other study tools. paclitaxel and carboplatin in early stage non-small-cell lung cancer: Early results of a completed phase II trial (abstract ).

Proc Am Soc Clin Oncol a, Depierre A, Milleron B, Moro D, et al: Phase III trial of neo-adjuvant chemotherapy in resectable stage I (except T1N0) II, IIIA, NSCLC: The French Experience (abstract ).Cited by: PURPOSE Due to decades of nonstandardized approaches to the naming of chemotherapy regimens, representation in electronic health records and secondary systems is highly variable.

This hampers efforts to understand patterns of chemotherapy usage at the population level. In this article, we describe a proposal for rules to standardize the nomenclature of chemotherapy regimens and illustrate Author: Samuel M. Rubinstein, Peter C.

Yang, Andrew J. Cowan, Jeremy L. Warner. of high‑dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel. Clin Pharmacol Ther ; – 84 Muindi JR, Potter DM, Peng Y, Johnson CS, T rump DL.

Adenocarcinoma is the most common type of NSCLC that accounts for 40% of all cases and the cancer originates in the peripheral lung tissue, i.e., the outer regions of the lung. Interestingly, this is also most common among nonsmokers, ex-smokers, or smokers with a modest smoking history.

Squamous-cell carcinoma is found centrally in the lung and is mostly associated with : Chitra Thakur. Serotonin antagonists are often used to counter nausea and vomiting resulting from powerful chemotherapy drugs such as cisplatin (Platinol and others) and cyclophosphamide (Cytoxan, Neosar and others).

Serotonin antagonists stop serotonin (a substance occurring naturally in the brain) from sending a signal that causes vomiting. However, new genetic and molecular testing techniques for peripheral T-cell lymphoma have enabled the development of targeted therapies for peripheral T-cell lymphoma treatment.

Newly diagnosed peripheral T-cell lymphoma patents are generally treated with anthracycline-based combination chemotherapy, including doxorubicin, hydroxydoxorubicin etc/5(21). Radiation therapy is a cancer treatment that involves sending high-energy beams of particles through the skin toward the tumor.

When the beams reach the tumor, they destroy the cancer cells by damaging their DNA. Radiation therapy is known for its particular effectiveness against head and neck tumors.

cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since Unfortunately, because of the severe side-effects like nephrotoxicity. Long term, high dose dexamethasone usually will produce predictable and potentially serious side effects.

Whenever possible, the lowest effective dose of dexamethasone should be used for the shortest possible length of time to minimize side effects. Alternate day dosing also can help reduce side effects. This phase I study characterized the pharmacokinetics of free and total platinum derived from cisplatin administered alone and in combination with pemetrexed.

Secondary objectives were to assess the pharmacokinetics of pemetrexed when it is combined with cisplatin as well as to evaluate the safety profile and document antitumor activity associated with this combination. An open-label, two Cited by:. 3. Molecular Mechanisms of Cisplatin and Lipoplatin.

After infusion, cisplatin is rapidly excreted in the urine causing renal tubular damage. When it reaches normal and malignant cells, it uses the major copper influx transporter Ctr1 for entry inside the cytoplasm (Figure 2).Ctr1 has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and by: General Information.

Chemotherapy and You - A comprehensive booklet from the National Cancer Institute. Available as a PDF, ePub or Kindle book. Chemotherapy for Patients: An Overview; - This site provides up to date and in depth information about all aspects of the chemotherapy experience.

Part of the Scott Hamilton CARES initiative.A chemotherapy regimen consisting of dexamethasone, high-dose cytarabine (ARA-C) and cisplatin (Platinol), used for the treatment of relapsed and refractory Hodgkin and non-Hodgkin lymphomas.

Check for active clinical trials using this agent. (NCI Thesaurus).